LogP | 2.316 at 25℃ |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
introduction | isopropyl 4-hydroxybenzoate is a carboxylate derivative, which can be used in soy sauce, vinegar, cool drinks (except soda), fruit flavoring, fruits and vegetables, pickled products, etc. It is also widely used in the fields of food, cosmetics, medicine, antiseptic, antifungal and fungicide. |
application | isopropyl 4-hydroxybenzoate (isopropyl paraben) is rarely used alone, and is often mixed with isopropyl ester, butyl ester, etc. Used as an oil-in-water emulsifier. The solubility of butyl ester is increased by 2~3 times. Easy to use in soy sauce. Isopropyl nipagin, like butyl p-hydroxybenzoate, can be used as a food preservation agent and antifungal agent. At present, there are 6 kinds of p-hydroxybenzoic acid esters allowed to be used in Japan, including ethyl ester, propyl ester, isopropyl ester, butyl ester, isobutyl ester and other butyl ester, among which butyl ester has the strongest antibacterial effect. Generally speaking, the larger the number of carbon atoms of the alcohol that constitutes the ester, the stronger the antibacterial effect, while the opposite is the toxicity. The smaller the number of carbon atoms, the greater the toxicity. The product has inhibitory or killing effects on various molds and yeasts, and is not affected by pH. Limited to soy sauce, vinegar, cool drinks, sherbet, fruit sauce, fruits and fruits vegetables (limited to the epidermis). The dosage is 1.4 times that of p-hydroxybenzoic acid. |
Preparation | It is obtained by esterification of p-hydroxybenzoic acid and isobutanol. The esterification reaction is carried out in the presence of sulfuric acid, using benzene or toluene as solvent, heating and reflux reaction to obtain isopropyl nipagin. According to the "Japanese Food Additives Public Agreement", the purity of the product should be above 99%. The toxicity of the product is relatively small, and the oral LD50 of mice is 8.38 g/kg. |
identification test | is the same as 1 and 2 items in the identification test of "ethyl p-hydroxybenzoate (07009). |
content analysis | is the same as "07009", but the sample does not need to be pre-dried. Each mLlmol/L sodium hydroxide solution is equivalent to 180.2mg of this product (C10H12O3). |
toxicity | LD50 7.17 g/kg (mouse, oral). |
use | preservative: antifungal. The function of 1g of this product is equivalent to 0.7664g p-hydroxybenzoic acid. |
Production method | It is obtained by esterification of p-hydroxybenzoic acid and isopropanol in the presence of sulfuric acid. |